In 2000, Ja Rule recorded the 1st single "Between Me and You", which was later featured on his second album. The song became an overnight hit. It made it to the 11th spot of Billboard Hot 100 and entered the UK Singles Chart on the 26th position. The second single, "Put It on Me", reached the 8th spot of Billboard Hot 100. For the first time Ja Rule’s work reached top-10 of that chart.
The second album, Rule 3:36, came out in October 2000 and topped Billboard 200 and Top R&B/Hip-Hop Albums. It was also a big hit in Canada, Germany, and the UK, where it reached high spots on the charts. The album sold over 4 million copies worldwide. Over 3 million were sold in the USA. The artist started touring the world. It became very hard to book Ja Rule for any event.
The lead single from the third LP, "Livin' It Up", came out in 2001. It reached the 6th spot of Billboard Hot 100 and came in fifth on UK Singles Chart. The second single “Always on Time” conquered Billboard Hot 100, Hot R&B/Hip-Hop Songs, and US Hot Rap Songs charts. It was also very successful in Canada, New Zealand, and Australia. Eleven other countries gave the single high positions.
In 2001, Ja Rule presented the 3rd studio LP, Pain Is Love. The album topped Billboard 200. It came in third in the UK and Canada. Just like the second LP, Pain Is Love earned a variety of platinum certifications. It sold over 6 million copies worldwide.
In 2002, the artist presented the fourth LP, The Last Temptation. It reached the 4th spot of Billboard 200 and sold over 1.5 million copies in the USA. A year later, Ja Rule released his fifth album, Blood in My Eye. It was named after George Jackson’s book. The LP reached the 6th spot on Billboard 200 and topped Top R&B/Hip-Hop Albums.
In 2004, the 6th LP, R.U.L.E., appeared. It scored high spots on Billboard 200 and UK Albums Chart. However, it was less successful than the rapper’s previous work. Only about 660,000 copies were sold in three years.
In 2005, Ja Rule released a compilation album called Exodus. After the release, the artist took a break from recording new music.
In 2009, Atkins founded an independent label Mpire Music Group.
In 2012, he released a new LP, Pain Is Love 2. The album barely made it into Billboard 20 where settled on the 197th position.
In 2014, the artist announced the release of a new album, Coup de Grâce. The fans are hoping to see it in 2018.