In 2010, Daniel landed one of the leading roles in the psychological thriller Chatroom. At the same time, Kaluuya worked in the theater. The premiere of Roy William’s Sucker Punch, in which Daniel had the leading part happened in 2010 on the stage of Jerwood Theatre Downstairs. That performance brought Daniel many positive reviews from the theater critics. He earned a prize at Evening Stand Awards in the "Outstanding Newcomer" category.
The same year, a comedy series Psychoville premiered on British TV. The young actor appeared in 13 episodes as Michael "Tealeaf" Fry. He also worked on a short film Baby, which earned many awards.
In 2011, Daniel played special agent Colin Tucker in the comedy Johnny English Reborn. He also appeared in several series, including Black Mirror and The Fades. The latter earned a BAFTA award as the best drama series of 2012.
In 2013, Kaluuya landed the role of Black Death in a superhero comedy Kick-Ass 2. At the same time, the actor was working on the movie Welcome to the Punch, in which he portrayed Juka Ogadowa.
The real breakthrough in Kaluuya’s acting career was the leading role in the horror movie Get Out. The film came out in 2017 and earned an Academy Award for the best script. It was also nominated for three awards, among which was Best Actor nomination, which belonged to Daniel.
The role also brought Kaluuya a prize at British Academy Film Awards in the "Rising Star Award" category. He was nominated for a Golden Globe award as "Best Actor – Motion Picture Musical or Comedy" and earned several more awards from MTV, African American Film Critics Association, and more. Altogether, the movie brought the actor 18 nominations and 9 awards. The success was so overwhelming that thousands of people wanted to book Daniel Kaluuya’s presence at their private events.
In 2018, Daniel portrayed the best friend of the main character in the Marvel movie Black Panther. Later this year, the fans are expecting to see Kaluuya in the crime drama Widows.