Since a wonderful tenor voice was coupled with handsome looks, Alessandro quickly became popular. Many people compared his looks to George Clooney’s. People magazine put him on its 50 most beautiful people list in 2000.
In 2002, Safina was invited to a prestigious event, Royal Variety Show, which took place in London. The event was attended by the British queen. Safina performed "Music of the Night" from Phantom of the Opera musical. The same year, Alessandro conquered the hearts of the American audience. He gave a concert in the ancient theater El Greco. The recording of this concert appeared on PBS. After the performance, the LP Alessandro Safina came out in the USA. The same year, Safina recorded “Your Song” with Elton John. Later, Alessandro joked that after performing with Elton John, he has only one dream left – to sing with U2.
In 2007, Safina recorded Sognami. The same year he released a successful single "Life Goes On", which was recorded together with a famous Netherland singer Petra Berger.
In 2014, Safina recorded Dedicated.
Alessandro Safina travels the world and gives an impressive number of concerts. The atmosphere at his concerts is so intriguing and relaxing that finding an empty seat is virtually impossible.