Busta decided to focus on a solo career. In 1996, he presented his debut studio LP, The Coming. For a debut album, it was extremely successful. The LP climbed to the 6th spot of Billboard 200 and sold over a million copies. The single, "Woo Hah!! Got You All in Check", reached the 8th spot on Billboard Hot 100. Songs "It's a Party", “Flipmode Squad Meets Def Squad", and "Keep It Movin'" became hits. Many event organizers started looking for ways to book Busta Rhymes.
In 1997, Rhymes released the second album, When Disaster Strikes... It climbed to the third spot of Billboard 200 and topped Top R&B Albums Chart. The songs "Dangerous", "Put Your Hands Where My Eyes Could See", and "Turn It Up" reached high spots on the charts as well.
A year later, the rapper presented his third LP. Extinction Level Event (Final World Front) sold over a million copies in the USA. It settled on the 12th spot of Billboard 200 and came in second on R&B/Hip-Hop Albums. The guest performers of the album were The Flipmode Squad, Mystikal, and Janet Jackson.
In 2000, Busta recorded another studio album, Anarchy. It was fairly commercially successful selling about 164,000 copies in the first week. The LP climbed to the 4th spot on Billboard 200.
In 2001, the artist presented Genesis. The album was recorded together with J. Blige, P. Diddy, Kelis, and Mary. It reached the 7th spot of Billboard 200 and sold over 185,000 copies in the first week. The single "Pass the Courvoisier Part II" reached the 11th spot on Billboard 200.